Gene Ontology

Gene ontology is a structured language holding information about the function of a gene. Jo Knight, Dr Mallar Chakravarty ( Computational Neuroscientist, Brain Imaging Centre, Douglas Institute) and graduate student Sejal Patel have developed a method to identify a priority gene list based on the molecular function of previously identified genes. All genetic data can then be analysed controlling for false discovery rate in a stratified framework potentially increasing the power to find a causal variant. They are now working to use this information in a machine learning framework alongside heritability measures for brain imaging phenotypes.